MicroSprayer® Aerosolizer for Rat — Model IA-1B-R

Model Number:
IA-1B-R

The MicroSprayer® Aerosolizer – Model IA-1B-R is designed for fast, targeted intratracheal aerosol administration to rat. The device can be used to administer a precisely quantifiable, highly-concentrated, air-free plume of liquid aerosol directly into the lungs or other locations. It may also be used for intranasal or in vitro applications. It can aerosolize a wide range of liquids or particle solutions/suspensions, including pharmaceutical and biologic formulations, contrast/imaging agents and toxicological materials. (It does not administer dry powders.)

For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation). The portion that is inserted into the trachea measures 2″. The Model IA-1B operates with either a 0.5 ml precision glass syringe or a 1 ml commercial polycarbonate syringe.

  • Quick, precise aerosol dosing directly to the lungs – with no waste
  • Purely mechanical, air-free technology
  • Uses no heat, propellant, ultrasound or compressed air. No air burden to subject.
  • Unique patented design is light weight, hand-held, easy to use
  • Rounded tip permits safe, gentle intratracheal insertion
  • Made of rigid stainless steel tubing and other chemically resistant components
  • Fully sterilizable, autoclavable and reusable
  • Delivers a far higher volume and concentration than is possible with nebulizer/inhalation systems
  • Produces a far broader, more uniform distribution than liquid bolus/droplet instillation methods
  • Materials: Based on rigid, 19-gauge, stainless steel tubing and other chemically resistant components.
  • 120-degree bend: All standard devices are made with a 120-degree bend to make it easier to see around one’s hand when trying to view the epiglottis. (Straight custom devices can be ordered.)
  • Length of intratracheal portion: 2″ (5 cm).
  • Tip is rounded to avoid harm to delicate tissues during insertion.
  • Operates with: Commercial, gas-tight 0.5ml precision glass syringe or 1 ml disposable polycarbonate syringe. NOTE: Due to the pressure required, syringes larger than 1 ml cannot be used to operate the Model 1A-1B.
  • Dose range: Designed to administer one dose at a time. Maximum dose size: 0.5 ml (glass) or 1 ml (polycarbonate). Smallest dose may need to be tested by end user. For doses larger than maximum capacity of the syringe, one syringe may be detached and refilled multiple times, or multiple syringes may be preloaded, attached and used one by one.
  • Outer diameter: .042″ (1.1 mm) except at tip which is .048″ (1.2 mm).
  • Inner diameter: .032″ (.813mm). (NOTE: liquid passes through patented aerosol components at the very tip. The diameter of these passageways is approximately 140 microns in diameter.)
  • Re-usable/Sterilizable: Can be cleaned and sterilized with very hot (filtered or distilled) water, organic solvents, by autoclave or ultrasound.

When analyzed with water, using the ml (1cc) polycarbonate syringe provided, the MicroSprayer® Aerosolizer – Model IA-1B produced a particle size distribution with a Mass Median Diameter (MMD) of 25-30 µm – when analyzed by laser defraction. NOTE: Results may vary, depending upon method of particle size analysis used, the material delivered and the length of the MicroSprayer® Aerosolizer

The following devices are helpful when working with the MicroSprayer® Aerosolizer – Model IA-1B in Rat:

    • Small Animal Laryngoscope – Model LS-2-R for RatSmall Animal Larygoscope

      Model Number: LS-2-R Description Specifications Diagram User Info Penn-Century’s Small Animal Laryngoscope Model LS-2-R is specifically designed for use in rat. It provides bright, clear illumination for better visualization of the trachea and epiglottis. It makes intratracheal intubation and insertion of Penn-Century’s MicroSprayer® Aerosolizers and Dry Powder Insufflators™ easier, quicker and safer. Each laryngoscope comes… Continue reading →

      $1,355.00
    • Intubation Platform for Rat – Model IPRIPR_platform_thumb

      Model Number: IPR Description Specifications Diagram User Info Intratracheal intubation in anesthetized rats can pose challenges due to variation in the animal’s size and weight as they age and the difficulty of visualizing the epiglottis. The Intubation Platform for Rat (IPR) by Penn-Century is a simple, durable, easy-to-use system. It is designed to support an… Continue reading →

      $790.00
    • Reverse Cleaning Adapter — Model RCA-1Bthumb-RCA-1B-adapter-parts-only-disconnected1

      Model Number: RCA-1B Description User Info A new tool to clear blockages in the tip of your MicroSprayer® Aerosolizer Model IA-1B. The Penn-Century MicroSprayer® Aerosolizer – Model IA-1B is a unique, air-free atomizer. It generates an aerosol when liquids, solutions or particle suspensions are pushed at high manual pressure through tiny patented aerosolizing components in… Continue reading →

      $55.00
    • 500 µl Glass Syringe0.5ml Glass Syringe

      Model Number: B-SYR-GL500 Description Commercial 0.5 ml (500 microliter) precision glass instrument syringe with luer-lock fitting. Sterilizable and reusable. This syringe can be used with any MicroSprayer® Aerosolizer Model IA-1B. Syringes are GAS-TIGHT and have a PTFE (Teflon™) plunger tip that creates a tight connection between the syringe barrel and plunger for optimal aerosol performance.… Continue reading →

      $95.00
    • 1 ml Polycarbonate Syringe1ml Polycarbonate Syringe

      Model Number: B-SYR-PL1000 Description Commercial 1 ml polycarbonate syringe with luer-lock fitting. Disposable. This syringe can be used with any MicroSprayer® Aerosolizer Model IA-1B. Syringes are GAS-TIGHT and have a silicone plunger tip that creates a tight connection between the syringe barrel and plunger. Male luer taper with a polycarbonate hub. Because of its larger… Continue reading →

      $3.90
Dimensions (approx.)
A B C
2″ 120° 1″
Key:

Length “A”: Functional length, from bend to tip
Angle “B”: Angle of bend
Length “C”: Length from hub to bend

For intratracheal applications, the MicroSprayer® Aerosolizer is typically inserted directly into the trachea. The intratracheal portion of the Model IA-1B-R is designed to reach from the front incisors to the carina in a standard size rat. NOTE: Users may also pre-intubate the animal and insert the device down the trachea to the carina via an endotracheal tube. Doing so requires that the user calculate the measurements carefully so that:

  1. the tip of the MicroSprayer® Aerosolizer is long enough to emerge slightly from the end of the endotracheal tube when it is in position, and
  2. neither the tip of ET tube nor the tip of MicroSprayer® Aerosolizer should make contact with the carina when the plunger of the syringe is pushed

Intratracheal use of Penn-Century devices
For best results, position the tip
of the device near to – but not
touching the carina, or first
bifurcation.

Intratracheal use of Penn-Century devices

The process of intratracheal administration is essentially a form of intubation. For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation). It operates with either a 1ml commercial polycarbonate syringe (provided) or a 0.5ml glass syringe (optional).

For other planning help, see our Instructions for Use of the MicroSprayer® Aerosolizer Model IA-1B.