The MicroSprayer® Aerosolizer – Model IA-1C-C can be made to any length – with a bend or straight. It is designed for fast, targeted intratracheal aerosol administration to a larger animal – via an endotracheal tube or a bronchoscope. It also can be made to order for other custom or in vitro applications. The device can be used to administer a precisely quantifiable, highly-concentrated, air-free plume of liquid aerosol directly into the lungs or other locations. It can aerosolize a wide range of liquids or particle solutions/suspensions, including pharmaceutical and biologic formulations, contrast/imaging agents and toxicological materials. (It does not administer dry powders.)

For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation). It requires use of Penn-Century’s patented FMJ-250 High Pressure Syringe. Larger doses can be administered by refilling and reattaching the syringe as many times as needed.

• Quick, precise aerosol dosing directly to the lungs – with no waste
• Purely mechanical, air-free technology
• Uses no heat, propellant, ultrasound or compressed air. No air burden to subject.
• Unique patented design is light, hand-held, easy to use
• Rounded tip permits safe, gentle intratracheal insertion
• Fully sterilizable, autoclavable and reusable
• Delivers a far higher volume and concentration than is possible with nebulizer/inhalation systems
• Produces a far broader, more uniform distribution than liquid bolus/droplet instillation methods

• Materials: Based on flexible, 23-gauge stainless steel tubing and other chemically resistant components
• Length of intratracheal portion: To be determined by user
• Straight or with 120-degree bend: Custom devices made are available on request either straight or with a 120-degree bend
• Tip is rounded to avoid harm to delicate tissues during insertion.
• Operates only with: Penn-Century’s patented FMJ-250 High Pressure Syringe (REQUIRED)
• Dose range: When used with FMJ-250 High Pressure Syringe, can administer dose volumes up to 250 microliters, or multiple smaller doses of 25 to 50 microliters or combinations of those dose volumes, using dosing spacers provided.
• Outer diameter: .025″ (0.64 mm), except at the very tip which is .028″ (0.71mm)
• Inner diameter: .017″ (0.43 mm) (NOTE: Liquid passes through patented aerosol components at the very tip. The diameter of these passageways in the Model IA-1C is approximately 60 microns in diameter. )
• Re-usable/Sterilizable: Can be cleaned and sterilized with very hot (filtered or distilled) water, organic solvents, by autoclave or ultrasound.

When analyzed with water, using Penn-Century’s FMJ-250 High Pressure Syringe, the MicroSprayer® Aerosolizer – Model IA-1C produced a particle size distribution with a Mass Median Diameter (MMD) of 16-22 µm (microns) – when analyzed by laser defraction. NOTE: Results may vary, depending upon method of particle size analysis used, the material delivered and the length of the MicroSprayer® Aerosolizer.

The following devices may be helpful when working with a custom length MicroSprayer® Aerosolizer – Model MSA-250:

All Penn-Century aerosol drug delivery devices are available in custom lengths for intratracheal or other uses in larger species, in other locations of the body, or in in-vitro, ex-vivo, or other experimental laboratory set-ups. The intratracheal portion (Length A) may be straight, or have a bend. For optimal intratracheal aerosol deposition in the lung and to avoid injury to the animal, the device must be measured correctly to assure that the portion inserted into the trachea is long enough to reach near to but not touching the carina (first bifurcation). In larger animals it may also be possible to insert the device in one lung, if desired. It is the responsibility of the user to determine the correct measurement for their particular use.

For custom devices, the length “A” must be specified, as shown:

NOTE: Thicker “stem” portion is not inserted into the trachea, endotracheal tube or bronchoscope.

For intratracheal applications in small animals, the MicroSprayer® Aerosolizer Model IA-1C is usually inserted directly into the trachea. The intratracheal portion of the Model IA-1C is designed to reach from the front incisors to the carina or beyond, depending upon the size of the animal used and method of insertion. NOTE: In larger animals users must insert the device via an endotracheal tube or bronchoscope. The device must be measured carefully to accommodate the method of insertion:

• If the Model IA-1C is inserted into the trachea via an endotracheal tube or bronchoscope, the distal tip must emerge slightly (approximately 1 cm) from the end of the endotracheal tube when it is in position. This will assure that the aerosol can freely pass beyond the first bifurcation into the lungs, or into an individual lung.
• The Model IA-1C is flexible, but should never be bent or forced into a sharp angle, or it will be damaged beyond repair.
• When measuring a custom length device via an endotracheal tube or bronchoscope, the user must take into account that some portion of the MicroSprayer® Aerosolizer will retract slightly into the endotracheal tube or bronchoscope when it is manipulated. Therefore, an additional amount of length must be added to compensate for this.
• To avoid injury to the animal, the distal tip of endotracheal tube and the distal tip of MicroSprayer® Aerosolizer should NEVER make contact with the carina when the plunger of the syringe is pushed.
• You will be required to confirm your final measurement prior to ordering.

The process of intratracheal administration is essentially a form of intubation. For intrapulmonary applications, the tip of the device is gently inserted down the trachea of the anesthetized animal – near to, but not touching the carina (first bifurcation).

For planning help, see our Instructions for Use of the MicroSprayer® Aerosolizer – IA-1C.