The delivery tube of the Dry Powder Insufflator™ – Model DP-4 is detachable and can be replaced with another delivery tube of a standard or custom length. Users may purchase an 18 gage stainless steel Extra Delivery Tube in a custom length specified by the user for intratracheal or intranasal, in vivo or ex vivo applications, or in vitro experimental laboratory set-ups. For example, custom-length devices can be ordered at the correct length for intratracheal insertion in: rabbits, ferrets, dogs, cats, chickens, pigs, sheep, monkeys, horses, etc. PLEASE NOTE: It is the user’s responsibility to determine the correct length of any custom device.
Detachable stainless steel or plastic delivery tube. The Dry Powder Insufflator™ is the only device made by Penn-Century in which the delivery tube can be ordered from either rigid, stainless steel or from flexible plastic. Depending on the size and anatomy of the animal or application, those who wish to order a custom length plastic delivery tube may insert the intratracheal portion directly or via an endotracheal tube to assure correct placement above the carina.
- To help us understand what device and length will best serve your needs, please complete and submit the Custom Device Questionnaire.
- To help you determine measurements for a custom length Model DP-4, click on the ‘Diagram’ tab on this page or download: Guide to Measuring a Custom-length Dry Powder Insufflator™ – Model DP-4
- For planning information on use of a custom length Model DP-4, see: Instructions for use of Penn-Century Dry Powder Insufflator™ – Model DP-4
The Dry Powder Insufflator™ – Model DP-4-C is designed for rapid, targeted, intratracheal powder administration. The stainless steel delivery tube of the device is attached to the device with a PEEK™ fitting. The delivery tube may be detached for cleaning, sterilization or autoclaving. Or it may be replaced with an Extra Delivery Tube of a longer or shorter intratracheal length for use of the Dry Powder Insufflator™ with a different experimental animal of another size or a different in vitro application. For pulmonary use, the intratracheal portion of the delivery tube must be long enough so that it can be positioned near but not touching the carina (first bifurcation) in an anesthetized animal.
A Custom length Extra Delivery Tube – Model DP-EXT-CPL can be ordered in flexible plastic at a length determined by the user. In larger animals, a flexible plastic delivery tube may be attached to the Dry Powder Insufflator™ and inserted to a point above the carina, or beyond the carina into one lung by inserting the plastic intratracheal portion down through the “working channel” (biopsy channel) of a bronchoscope.
- Extra Delivery Tube designed for use only with Dry Powder Insufflator™ – Model DP-4
- Attaches to the device with a PEEK™ plastic fitting
- Sterilizable by liquid or dry methods. Must be thoroughly dried before use.
- Delivery tube: Choice of rigid, hollow stainless steel 18-gauge tubing with rounded tip – straight or with 120-degree bend, or custom-extruded flexible plastic.
- Length of intratracheal portion: Determined by the user
- Outer diameter: .050″ (1.1 mm) except at rounded tip which is .058″
- Inner diameter: .038″ (Hollow throughout)
- Reusable/Sterilizable: Stainless steel tip detachable, cleanable with liquid methods, and autoclavable. Flexible plastic tubing and PEEK™ plastic hub are detachable, and can be cleaned with liquid methods, and autoclavable. NOTE: Dry methods of cleaning are preferred for Air Intake and Sample Chamber Dry Powder Insufflator™.
Determining measurements for custom-length devices
All Penn-Century aerosol drug delivery devices are available in custom lengths for intratracheal or other uses in larger species, in other locations of the body, or in in-vitro, ex-vivo, or other experimental laboratory set-ups. The delivery tube (Length A) may be straight, or have a bend.
For optimal intratracheal aerosol deposition in the lung and to avoid injury to the animal, the device must be measured correctly to assure that the portion inserted into the trachea is long enough to reach near to but not touching the carina (first bifurcation). In larger animals it may also be possible to insert the device in one lung, if desired. It is the responsibility of the user to provide Penn-Century with the correct measurement for their particular use. For assistance, see our Guide to Measuring a Custom-length Dry Powder Insufflator™ – Model DP-4.
Delivery tube of Dry Powder Insufflator™ – Model DP-4-C for Custom Lengths
For custom length, straight devices, the length “A” must be specified, as shown:
Length “A”: Functional length, from bend to tip
Angle “B”: Angle of bend
Length “C”: Length from hub to bend
For intratracheal applications with the Dry Powder Insufflator™ optimal concentration and uniform deposition in the lung is achieved when the tip of the device is close to but not touching the carina. The intratracheal portion of the delivery tube (A) must reach from the front incisors to the carina or beyond, depending on the experimental use and method of insertion.
Users may also pre-intubate the animal and insert the device down the trachea to the carina via an endotracheal tube. Doing so requires that the user calculate the measurements carefully:
- If tip of the Dry Powder Insufflator™ is inserted into an endotracheal tube, the distal tip must emerge slightly from the end of the endotracheal tube when it is in position
- To avoid injury, neither the distal tip of endotracheal tube nor the distal tip of the Dry Powder Insufflator™ should make contact with the carina when the plunger of the air syringe is pushed
For complete details, please refer to the Instructions for Use of the Dry Powder Insufflator™ – Model DP-4
Cleaning the Custom length Extra Delivery Tube – Model DP-EXT-C
The delivery tube of the device is hollow and detachable, and may be cleaned separately. The device may be autoclaved or immersed in water, organic solvent or disinfectant. It should be thoroughly and completely dried – using compressed air or by air drying it – prior to reattaching to the body of the device.
- To remove the delivery tube, firmly grasp the PEEK™ hub fitting
- Twist it ¼-turn counterclockwise
- Pull out the stainless steel tube.
- Once it is removed, the delivery tube and hub should be thoroughly cleaned and completely dried – using compressed air or by air drying it, prior to reattaching it to the body of the device.
- To reattach, push the stainless steel tube into the hub until it makes a hard stop
- Turn the fitting 1/4-turn clockwise, or until some resistance is felt.
- Do not overtighten.