The Dry Powder Insufflator™ – Model DP-4-C is designed for rapid, targeted, intratracheal powder administration. The stainless steel delivery tube of the device is attached to the device with a PEEK™ fitting. The delivery tube may be detached for cleaning, sterilization or autoclaving. Or it may be replaced with an Extra Delivery Tube of a longer or shorter intratracheal length for use of the Dry Powder Insufflator™ with a different experimental animal of another size or a different in vitro application. For pulmonary use, the intratracheal portion of the delivery tube must be long enough so that it can be positioned near but not touching the carina (first bifurcation) in an anesthetized animal.

A Custom length Extra Delivery Tube – Model DP-EXT-CPL can be ordered in flexible plastic at a length determined by the user. In larger animals, a flexible plastic delivery tube may be attached to the Dry Powder Insufflator™ and inserted to a point above the carina, or beyond the carina into one lung by inserting the plastic intratracheal portion down through the “working channel” (biopsy channel) of a bronchoscope.

• Extra Delivery Tube designed for use only with Dry Powder Insufflator™ – Model DP-4
• Attaches to the device with a PEEK™ plastic fitting
• Sterilizable by liquid or dry methods. Must be thoroughly dried before use.

• Delivery tube: Choice of rigid, hollow stainless steel 18-gauge tubing with rounded tip – straight or with 120-degree bend, or custom-extruded flexible plastic.
• Length of intratracheal portion: Determined by the user
• Outer diameter: .050″ (1.1 mm) except at rounded tip which is .058″
• Inner diameter: .038″ (Hollow throughout)
• Reusable/Sterilizable: Stainless steel tip detachable, cleanable with liquid methods, and autoclavable. Flexible plastic tubing and PEEK™ plastic hub are detachable, and can be cleaned with liquid methods, and autoclavable. NOTE: Dry methods of cleaning are preferred for Air Intake and Sample Chamber Dry Powder Insufflator™.

The Penn-Century Dry Powder Insufflator™ – Model DP-4 consists of an Air Intake and Sample Chamber to which a hollow delivery tube is connected. The device twists open at the center to permit the Sample Chamber to be filled manually with a small single dose (1 – 5 mg) of powdered material, using with a narrow spatula. The two halves are then gently but firmly press-fit back together, protecting the powder sample from ambient air and moisture. The tip of the air source, either the 3 ml air syringe or the Penn-Century Air Pump, is then inserted into the opening at the back of the Air Handler. The delivery tube is made of stainless steel and is attached to the device by a PEEK™ fitting. The tube and fitting can be unscrewed from the Sample Chamber and cleaned separately using wet methods if desired. It must be thoroughly dried before reattaching to the device. NOTE: Powder should never be loaded into the Air Handler as this may prevent the device from functioning properly.

Determining measurements for custom-length devices

All Penn-Century aerosol drug delivery devices are available in custom lengths for intratracheal or other uses in larger species, in other locations of the body, or in in-vitro, ex-vivo, or other experimental laboratory set-ups. The delivery tube (Length A) may be straight, or have a bend.

For optimal intratracheal aerosol deposition in the lung and to avoid injury to the animal, the device must be measured correctly to assure that the portion inserted into the trachea is long enough to reach near to but not touching the carina (first bifurcation). In larger animals it may also be possible to insert the device in one lung, if desired. It is the responsibility of the user to provide Penn-Century with the correct measurement for their particular use. For assistance, see our Guide to Measuring a Custom-length Dry Powder Insufflator™ – Model DP-4.

Delivery tube of Dry Powder Insufflator™ – Model DP-4-C for Custom Lengths

For custom length, straight devices, the length “A” must be specified, as shown:

For intratracheal applications with the Dry Powder Insufflator™ optimal concentration and uniform deposition in the lung is achieved when the tip of the device is close to but not touching the carina. The intratracheal portion of the delivery tube (A) must reach from the front incisors to the carina or beyond, depending on the experimental use and method of insertion.

Users may also pre-intubate the animal and insert the device down the trachea to the carina via an endotracheal tube. Doing so requires that the user calculate the measurements carefully:

1. If tip of the Dry Powder Insufflator™ is inserted into an endotracheal tube, the distal tip must emerge slightly from the end of the endotracheal tube when it is in position
2. To avoid injury, neither the distal tip of endotracheal tube nor the distal tip of the Dry Powder Insufflator™ should make contact with the carina when the plunger of the air syringe is pushed

For complete details, please refer to the Instructions for Use of the Dry Powder Insufflator™ – Model DP-4

Cleaning the Custom length Extra Delivery Tube – Model DP-EXT-C

The delivery tube of the device is hollow and detachable, and may be cleaned separately. The device may be autoclaved or immersed in water, organic solvent or disinfectant. It should be thoroughly and completely dried – using compressed air or by air drying it – prior to reattaching to the body of the device.

1. To remove the delivery tube, firmly grasp the PEEK™ hub fitting
2. Twist it ¼-turn counterclockwise
3. Pull out the stainless steel tube.
4. Once it is removed, the delivery tube and hub should be thoroughly cleaned and completely dried – using compressed air or by air drying it, prior to reattaching it to the body of the device.
5. To reattach, push the stainless steel tube into the hub until it makes a hard stop
6. Turn the fitting 1/4-turn clockwise, or until some resistance is felt.
7. Do not overtighten.